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apalutamide will minimize the extent or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medications which can be CYP3A4 substrates may result in decreased exposure to those drugs.Minimal (one)modafinil will improve the a